Author(s)
Mallika Sastry
Published 2 Projects
Immunology Immune Evasion Structural Rearrangement Type 1 Cr3022
Yaroslav Tsybovsky
Published 9 Projects
COVID-19 Immunology Synthetic Biology Antibody Immune Evasion
Content
Video Abstract (AI generated) (01:17) Paper Preprint Nature MedicineA central goal of HIV-1-vaccine research is the elicitation of antibodies capable of neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune response to exposed N-terminal residues of the fusion peptide, a critical component of the viral entry machinery and the epitope of antibodies elicited by HIV-1 infection, through immunization with fusion peptide-coupled carriers and prefusion-stabilized envelope trimers, induces cross-clade neutralizing responses. In mice, these immunogens elicited monoclonal antibodies capable of neutralizing up to 31% of a cross-clade panel of 208 HIV-1 strains. Crystal and cryo-electron microscopy structures of these antibodies revealed fusion peptide-conformational diversity as a molecular explanation for the cross-clade neutralization. Immunization of guinea pigs and rhesus macaques induced similarly broad fusion peptide-directed neutralizing responses suggesting translatability. The N terminus of the HIV-1-fusion peptide is thus a promising target of vaccine efforts aimed at eliciting broadly neutralizing antibodies.
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Yaroslav Tsybovsky. (2021, Nov 1).Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1[Video]. Scitok. https://scitok.com/project/p/eaf916c6
Xu Kai. "Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1" Scitok, uploaded by Tsybovsky Yaroslav, 1 Nov, 2021, https://scitok.com/project/peaf916c6
Yaroslav Tsybovsky. "Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1" Scitok. (Nov 1, 2021). https://scitok.com/project/p/eaf916c6
Yaroslav Tsybovsky (Nov 1, 2021). Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 Scitok. https://scitok.com/project/p/eaf916c6
Yaroslav Tsybovsky. Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1[video]. 2021 Nov 1. https://scitok.com/project/p/eaf916c6
@online{al2006link, title={ Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 }, author={ Tsybovsky, Yaroslav }, organization={Scitok}, month={ Nov }, day={ 1 }, year={ 2021 }, url = {https://scitok.com/project/p/eaf916c6}, }