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Video Abstract (AI generated) (01:37) Paper PreprintSARS-CoV-2 is a novel ssRNA+ virus from the Coronaviridae family, which has caused the global COVID-19 pandemic. The genome of SARS-CoV-2 is one of the largest of RNA viruses, comprising of 26 known protein-coding loci. This study aimed to explore the coding potential of negative-strand RNA intermediate for its potential to contain additional protein coding-loci. Surprisingly, we have found several putative ORFs and one brandt new functional SARS-CoV-2 protein-coding loci and called it Avo1 (Ambient viral ORF1). This sequence is located on negative-sense RNA intermediate and bona fide coding for 81 amino acid residues long protein and contains strong Kozak sequence for translation on eukaryotic ribosomes. In silico translated protein Avo1 has a predominantly alpha-helical structure. The existence of Avo1 gene is supported also by its evolutionarily and structural conservation in RaTG13 bat coronavirus. The nucleotide sequence of Avo1 also contains a unique SREBP2 binding site which is closely related to the so-called cytokine storm in severe COVID-19 patients. Altogether, our results suggest the existence of still undescribed SARS-CoV-2 protein, which may play an important role in the viral lifecycle and COVID-19 pathogenesis.
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Martin Bartas. (2021, Oct 1).Unheeded SARS-CoV-2 protein? Look deep into negative-sense RNA[Video]. Scitok. https://scitok.com/project/p/e93355e7
Bartas Martin. "Unheeded SARS-CoV-2 protein? Look deep into negative-sense RNA" Scitok, uploaded by Bartas Martin, 1 Oct, 2021, https://scitok.com/project/pe93355e7
Martin Bartas. "Unheeded SARS-CoV-2 protein? Look deep into negative-sense RNA" Scitok. (Oct 1, 2021). https://scitok.com/project/p/e93355e7
Martin Bartas (Oct 1, 2021). Unheeded SARS-CoV-2 protein? Look deep into negative-sense RNA Scitok. https://scitok.com/project/p/e93355e7
Martin Bartas. Unheeded SARS-CoV-2 protein? Look deep into negative-sense RNA[video]. 2021 Oct 1. https://scitok.com/project/p/e93355e7
@online{al2006link, title={ Unheeded SARS-CoV-2 protein? Look deep into negative-sense RNA }, author={ Bartas, Martin }, organization={Scitok}, month={ Oct }, day={ 1 }, year={ 2021 }, url = {https://scitok.com/project/p/e93355e7}, }