Author(s)
Jignesh H. Parmar
Published 3 Projects
Iron Metabolism Microbiology Systems Biology Homeostasis Pseudomonas Aeruginosa
Pedro Mendes
Published 8 Projects
Iron Metabolism Microbiology Cancer Biology Systems Biology Introduction
Content
Video Abstract (AI generated) (01:42) Paper Preprint BMC Systems BiologyBackground: Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative diseases. Here we test the hypothesis that hepcidin alone is able to regulate iron distribution in different dietary regimes in the mouse using a computational model of iron distribution calibrated with radioiron tracer data. Results: A model was developed and calibrated to the data from adequate iron diet, which was able to simulate the iron distribution under a low iron diet. However simulation of high iron diet shows considerable deviations from the experimental data. Namely the model predicts more iron in red blood cells and less iron in the liver than what was observed in experiments. Conclusions: These results suggest that hepcidin alone is not sufficient to regulate iron homeostasis in high iron conditions and that other factors are important. The model was able to simulate anemia when hepcidin was increased but was unable to simulate hemochromatosis when hepcidin was suppressed, suggesting that in high iron conditions additional regulatory interactions are important.
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Pedro Mendes. (2021, Nov 5).Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient[Video]. Scitok. https://scitok.com/project/p/c634cb05
H. Parmar Jignesh. "Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient" Scitok, uploaded by Mendes Pedro, 5 Nov, 2021, https://scitok.com/project/pc634cb05
Pedro Mendes. "Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient" Scitok. (Nov 5, 2021). https://scitok.com/project/p/c634cb05
Pedro Mendes (Nov 5, 2021). Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient Scitok. https://scitok.com/project/p/c634cb05
Pedro Mendes. Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient[video]. 2021 Nov 5. https://scitok.com/project/p/c634cb05
@online{al2006link, title={ Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient }, author={ Mendes, Pedro }, organization={Scitok}, month={ Nov }, day={ 5 }, year={ 2021 }, url = {https://scitok.com/project/p/c634cb05}, }