Author(s)
Daniel Stadlbauer
Published 9 Projects
COVID-19 Coronavirus SARS-CoV-2 Epidemiology Infectious Diseases
Fatima Amanat
Published 24 Projects
Infectious Diseases Epidemiology Allergy And Immunology Immunology Covid19
Kaijun Jiang
Published 5 Projects
Microbiology Epidemiology Infectious Diseases Allergy And Immunology
Content
Video Abstract (AI generated) (01:27) Paper PreprintWhile the current pandemic remains a thread to human health, the polyclonal nature of the antibody response against SARS-CoV-2 is not fully understood. Other than SARS-CoV-2, humans are susceptible to six different coronaviruses, and previous exposure to antigenically related and divergent seasonal coronaviruses is frequent. We longitudinally profiled the early humoral immune response against SARS-CoV-2 on hospitalized COVID-19 patients, and quantify levels of pre-existing immunity to OC43, HKU1 and 223E seasonal coronaviruses. A strong back-boosting effect to conserved, but not variable regions of OC43 and HKU1 betacoronaviruses spike protein was observed. All patients developed antibodies against SARS-CoV-2 spike and nucleoprotein, with peak induction at day 7 post hospitalization. However a negative correlation was found between antibody memory boost to human coronaviruses and induction of IgG and IgM against SARS-CoV-2 spike. Our findings provide evidence of immunological imprinting that determine the antibody profile to COVID-19 patients in an original antigenic sin fashion.
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Florian Krammer. (2021, Oct 30).Antibody Immunological Imprinting on COVID-19 Patients[Video]. Scitok. https://scitok.com/project/p/bcfdbe92
Aydillo Teresa. "Antibody Immunological Imprinting on COVID-19 Patients" Scitok, uploaded by Krammer Florian, 30 Oct, 2021, https://scitok.com/project/pbcfdbe92
Florian Krammer. "Antibody Immunological Imprinting on COVID-19 Patients" Scitok. (Oct 30, 2021). https://scitok.com/project/p/bcfdbe92
Florian Krammer (Oct 30, 2021). Antibody Immunological Imprinting on COVID-19 Patients Scitok. https://scitok.com/project/p/bcfdbe92
Florian Krammer. Antibody Immunological Imprinting on COVID-19 Patients[video]. 2021 Oct 30. https://scitok.com/project/p/bcfdbe92
@online{al2006link, title={ Antibody Immunological Imprinting on COVID-19 Patients }, author={ Krammer, Florian }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/bcfdbe92}, }