Author(s)
Xueyong Zhu
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Ian A. Wilson
Published 14 Projects
Biophysics Immunology Molecular Biology Neuroscience Hemagglutinin Inhibitor
Content
Video Abstract (AI generated) (01:55) Paper Preprint CellThe emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies (mAbs) from ten COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb CV07-209 neutralized authentic SARS-CoV-2 with IC50 of 3.1 ng/ml. Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 A revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2 neutralizing mAbs reacted with mammalian self-antigens. Prophylactic and therapeutic application of CV07-209 protected hamsters from SARS-CoV-2 infection, weight loss and lung pathology. Our results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy. ### Competing Interest Statement Related to this work the German Center for Neurodegenerative Diseases (DZNE) and the Charite - Universitaetsmedizin have filed a patent application on which JK, SMR, HCK, ESS, VMC, MAM, DW, LES and HP are named as inventors.
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Xueyong Zhu. (2021, Nov 6).A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model[Video]. Scitok. https://scitok.com/project/p/b6bb2474
Kreye Jakob. "A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model" Scitok, uploaded by Zhu Xueyong, 6 Nov, 2021, https://scitok.com/project/pb6bb2474
Xueyong Zhu. "A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model" Scitok. (Nov 6, 2021). https://scitok.com/project/p/b6bb2474
Xueyong Zhu (Nov 6, 2021). A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model Scitok. https://scitok.com/project/p/b6bb2474
Xueyong Zhu. A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model[video]. 2021 Nov 6. https://scitok.com/project/p/b6bb2474
@online{al2006link, title={ A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model }, author={ Zhu, Xueyong }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/b6bb2474}, }