Author(s)
Hailiang Huang
Published 18 Projects
Panss Expression Quantitative Trait Locus Genetics Meta Analysis Genetic And Genomic Medicine
Soumya Raychaudhuri
Published 2 Projects
Genetics Genetic And Genomic Medicine Inflammatory Bowel Diseases (Ibd) Hla Fine Mapping
Content
Video Abstract (AI generated) (01:41) Paper Preprint (github,"") (github,"") (data,broadinstitute) (www,internationalgenome) Data/Code Data/CodeMany diseases and complex traits exhibit population-specific causal effect sizes with trans-ethnic genetic correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We developed a new method, S-LDXR, for stratifying squared trans-ethnic genetic correlation across genomic annotations, and applied S-LDXR to genome-wide association summary statistics for 31 diseases and complex traits in East Asians (EAS) and Europeans (EUR) (average N EAS=90K, N EUR=267K) with an average trans-ethnic genetic correlation of 0.85 (s.e. 0.01). We determined that squared trans-ethnic genetic correlation was 0.82× (s.e. 0.01) smaller than the genome-wide average at SNPs in the top quintile of background selection statistic, implying more population-specific causal effect sizes. Accordingly, causal effect sizes were more population-specific in functionally important regions, including conserved and regulatory regions. In analyses of regions surrounding specifically expressed genes, causal effect sizes were most population-specific for skin and immune genes and least population-specific for brain genes. Our results could potentially be explained by stronger gene-environment interaction at loci impacted by selection, particularly positive selection. ### Competing Interest Statement The authors have declared no competing interest.
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Hailiang Huang. (2021, Oct 27).Population-specific causal disease effect sizes in functionally important regions impacted by selection[Video]. Scitok. https://scitok.com/project/p/6cf59cf2
Shi Huwenbo. "Population-specific causal disease effect sizes in functionally important regions impacted by selection" Scitok, uploaded by Huang Hailiang, 27 Oct, 2021, https://scitok.com/project/p6cf59cf2
Hailiang Huang. "Population-specific causal disease effect sizes in functionally important regions impacted by selection" Scitok. (Oct 27, 2021). https://scitok.com/project/p/6cf59cf2
Hailiang Huang (Oct 27, 2021). Population-specific causal disease effect sizes in functionally important regions impacted by selection Scitok. https://scitok.com/project/p/6cf59cf2
Hailiang Huang. Population-specific causal disease effect sizes in functionally important regions impacted by selection[video]. 2021 Oct 27. https://scitok.com/project/p/6cf59cf2
@online{al2006link, title={ Population-specific causal disease effect sizes in functionally important regions impacted by selection }, author={ Huang, Hailiang }, organization={Scitok}, month={ Oct }, day={ 27 }, year={ 2021 }, url = {https://scitok.com/project/p/6cf59cf2}, }