Author(s)
Viviana Simon
Published 15 Projects
Infectious Diseases Epidemiology Immunology Allergy And Immunology Nosocomial Outbreak
Content
Video Abstract (AI generated) (01:11) Paper PreprintUnderstanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at [≥] 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.
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Florian Krammer. (2021, Oct 30).Immunological memory to SARS-CoV-2 assessed for up to eight months after infection[Video]. Scitok. https://scitok.com/project/p/5514a3f8
M Dan Jennifer. "Immunological memory to SARS-CoV-2 assessed for up to eight months after infection" Scitok, uploaded by Krammer Florian, 30 Oct, 2021, https://scitok.com/project/p5514a3f8
Florian Krammer. "Immunological memory to SARS-CoV-2 assessed for up to eight months after infection" Scitok. (Oct 30, 2021). https://scitok.com/project/p/5514a3f8
Florian Krammer (Oct 30, 2021). Immunological memory to SARS-CoV-2 assessed for up to eight months after infection Scitok. https://scitok.com/project/p/5514a3f8
Florian Krammer. Immunological memory to SARS-CoV-2 assessed for up to eight months after infection[video]. 2021 Oct 30. https://scitok.com/project/p/5514a3f8
@online{al2006link, title={ Immunological memory to SARS-CoV-2 assessed for up to eight months after infection }, author={ Krammer, Florian }, organization={Scitok}, month={ Oct }, day={ 30 }, year={ 2021 }, url = {https://scitok.com/project/p/5514a3f8}, }