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Russ Altman
Published 17 Projects
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Video Abstract (AI generated) (01:37) Paper Preprint European Journal of Human GeneticsSex differences have been shown in laboratory biomarkers; however, the extent to which this is due to genetics is unknown. In this study, we infer sex-specific genetic parameters (heritability and genetic correlation) across 33 quantitative biomarker traits in 181,064 females and 156,135 males from the UK Biobank study. We apply a Bayesian mixture model, Sex Effects Mixture Model, to Genome-wide Association Study summary statistics in order to (1) estimate the contributions of sex to the genetic variance of these biomarkers and (2) identify variants whose statistical association with these traits is sex-specific. We find that the genetics of most biomarker traits are shared between males and females, with the notable exception of testosterone, where we identify 119 female and 444 male-specific variants. These include protein-altering variants in steroid hormone production genes (POR, CYP3A43, UGT2B7). Using the sex-specific variants as genetic instruments for Mendelian Randomization, we find evidence for causal links between testosterone levels and height, body mass index, waist circumference, and type 2 diabetes. We also show that sex-specific polygenic risk score models for testosterone outperform a combined model. Overall, these results demonstrate that while sex has a limited role in the genetics of most biomarker traits, sex plays an important role in testosterone genetics.
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Russ Altman. (2021, Oct 26).Sex-specific genetic effects across biomarkers[Video]. Scitok. https://scitok.com/project/p/4af3ea0c
Flynn Emily. "Sex-specific genetic effects across biomarkers" Scitok, uploaded by Altman Russ, 26 Oct, 2021, https://scitok.com/project/p4af3ea0c
Russ Altman. "Sex-specific genetic effects across biomarkers" Scitok. (Oct 26, 2021). https://scitok.com/project/p/4af3ea0c
Russ Altman (Oct 26, 2021). Sex-specific genetic effects across biomarkers Scitok. https://scitok.com/project/p/4af3ea0c
Russ Altman. Sex-specific genetic effects across biomarkers[video]. 2021 Oct 26. https://scitok.com/project/p/4af3ea0c
@online{al2006link, title={ Sex-specific genetic effects across biomarkers }, author={ Altman, Russ }, organization={Scitok}, month={ Oct }, day={ 26 }, year={ 2021 }, url = {https://scitok.com/project/p/4af3ea0c}, }