Author(s)
Taushif Khan
Published 6 Projects
COVID-19 Immunology Autoimmunity Microbiology Bioinformatics
Mahbuba Rahman
Published 3 Projects
Immunology Microbiology Herpesviruses Herpes Simplex Virus Picornaviruses
Content
Video Abstract (AI generated) (01:43) Paper Preprint Supplementary Material Supplementary Tables S3 and S4Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans. B cell responses to these “common cold” viruses remain incompletely understood. Here we report a comprehensive analysis of CoV-specific antibody repertoires in 231 children and 1168 adults using phage-immunoprecipitation sequencing. Seroprevalence of antibodies to endemic HCoVs ranged between ~4 and 27% depending on the species and cohort. We identified at least 136 novel linear B cell epitopes. Antibody repertoires against endemic HCoVs were qualitatively different between children and adults in that anti-HCoV IgG specificities more frequently found among children targeted functionally important and structurally conserved regions of the spike, nucleocapsid and matrix proteins. Moreover, antibody specificities targeting the highly conserved fusion peptide region and S2’ cleavage site of the spike protein were broadly cross-reactive with peptides of epidemic human and non-human coronaviruses. In contrast, an acidic tandem repeat in the N-terminal region of the Nsp3 subdomain of the HCoV-HKU1 polyprotein was the predominant target of antibody responses in adult donors. Our findings shed light on the dominant species-specific and pan-CoV target sites of human antibody responses to coronavirus infection, thereby providing important insights for the development of prophylactic or therapeutic monoclonal antibodies and vaccine design. ### Competing Interest Statement The authors have declared no competing interest.
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Taushif Khan. (2021, Oct 24).Distinct antibody repertoires against endemic human coronaviruses in children and adults[Video]. Scitok. https://scitok.com/project/p/3e598ff7
Khan Taushif. "Distinct antibody repertoires against endemic human coronaviruses in children and adults" Scitok, uploaded by Khan Taushif, 24 Oct, 2021, https://scitok.com/project/p3e598ff7
Taushif Khan. "Distinct antibody repertoires against endemic human coronaviruses in children and adults" Scitok. (Oct 24, 2021). https://scitok.com/project/p/3e598ff7
Taushif Khan (Oct 24, 2021). Distinct antibody repertoires against endemic human coronaviruses in children and adults Scitok. https://scitok.com/project/p/3e598ff7
Taushif Khan. Distinct antibody repertoires against endemic human coronaviruses in children and adults[video]. 2021 Oct 24. https://scitok.com/project/p/3e598ff7
@online{al2006link, title={ Distinct antibody repertoires against endemic human coronaviruses in children and adults }, author={ Khan, Taushif }, organization={Scitok}, month={ Oct }, day={ 24 }, year={ 2021 }, url = {https://scitok.com/project/p/3e598ff7}, }